Everyone using Pluto should read these pages. They will demonstrate how to interact with RF signals with MATLAB, Simulink, GNU Radio or custom C, C++, C#, or Python code on a host (x86) or embedded (Raspberry Pi, Beaglebone, 96boards.org, etc.) platform over USB. As you can see, we have lots of examples with MATLAB and Simulink, as we find that a very powerful environment, and a path to a releasable radio (you can take your algorithms, and easily embed them into a custom product).
Make sure all things are in ./users